Journal article
A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease
Abstract
Cellular stress is a normal part of the aging process and is especially relevant in neurodegenerative disease. Canonical stress responses, such as the heat shock response, activate following exposure to stress and restore proteostasis through the action of isomerases and chaperones within the cytosol. Through live-cell imaging, we demonstrate involvement of the Huntington's disease (HD) protein, huntingtin, in a rapid cell stress response that …
Authors
Nath S; Munsie LN; Truant R
Journal
Human Molecular Genetics, Vol. 24, No. 2, pp. 450–462
Publisher
Oxford University Press (OUP)
Publication Date
January 15, 2015
DOI
10.1093/hmg/ddu460
ISSN
0964-6906