Journal article
Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization
Abstract
The N17 domain of the huntingtin protein is post-translationally modified and is the master regulator of huntingtin intracellular localization. In Huntington's disease (HD), mutant huntingtin is hypo-phosphorylated at serines 13 and 16 within N17, and increasing N17 phosphorylation has been shown to be protective in HD mouse models. Thus, N17 phosphorylation is defined as a sub-target of huntingtin for potential therapeutic intervention. We …
Authors
DiGiovanni LF; Mocle AJ; Xia J; Truant R
Journal
Human Molecular Genetics, Vol. 25, No. 18, pp. 3937–3945
Publisher
Oxford University Press (OUP)
Publication Date
September 15, 2016
DOI
10.1093/hmg/ddw234
ISSN
0964-6906