Journal article
Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
Abstract
BACKGROUND & AIMS: We established the concept that transient enteric infection may lead to persistent gut dysfunction, evident in vitro, in nematode-infected mice. The present study determined whether gut dysfunction in this model involves motor and sensory changes reminiscent of changes found in patients with postinfective irritable bowel syndrome (PI-IBS) and investigated underlying mechanisms.
METHODS: Mice infected up to 70 days previously …
Authors
Bercı́k P; Wang L; Verdú EF; Mao YK; Blennerhassett P; Khan WI; Kean I; Tougas G; Collins SM
Journal
Gastroenterology, Vol. 127, No. 1, pp. 179–187
Publisher
Elsevier
Publication Date
July 2004
DOI
10.1053/j.gastro.2004.04.006
ISSN
0016-5085