Journal article
Lung cancer chemotherapy agents increase procoagulant activity via protein disulfide isomerase-dependent tissue factor decryption
Abstract
Lung cancer patients undergoing chemotherapy have an elevated risk for thrombosis. However, the mechanisms by which chemotherapy agents increase the risk for thrombosis remains unclear. The aim of this study was to determine the mechanism(s) by which lung cancer chemotherapy agents cisplatin, carboplatin, gemcitabine, and paclitaxel elicit increased tissue factor activity on endothelial cells, A549 cells, and monocytes. Tissue factor activity, …
Authors
Lysov Z; Swystun LL; Kuruvilla S; Arnold A; Liaw PC
Journal
Blood Coagulation & Fibrinolysis, Vol. 26, No. 1, pp. 36–45
Publisher
Wolters Kluwer
Publication Date
January 2015
DOI
10.1097/mbc.0000000000000145
ISSN
0957-5235