Journal article
Factors that contribute to the immmunogenicity of therapeutic recombinant human proteins
Abstract
Use of recombinant human proteins has revolutionized medicine by providing over 200 highly purified hormones and proteins that effectively treat many inherited and acquired peptide hormone and protein deficiencies. With the exception of therapeutic monoclonal antibodies, these biological medicines are synthesized by cultured cells using DNA sequences that would yield proteins with identical amino acid sequences as endogenous human proteins. …
Authors
Mukovozov I; Sabljic T; Hortelano G; Ofosu FA
Journal
Thrombosis and Haemostasis, Vol. 99, No. 05, pp. 874–882
Publisher
Thieme
Publication Date
2008
DOI
10.1160/th07-11-0654
ISSN
0340-6245