Journal article
Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase
Abstract
The herpes simplex virus ribonucleotide reductase is associated with two viral proteins which are both immunoprecipitated by monoclonal antibodies specific for the enzyme. We separated the two proteins and showed that individual antibodies react solely with one or the other. In addition, antibodies to either protein can neutralize enzymatic activity. Our data demonstrate that the proteins are associated in a complex and constitute the subunits …
Authors
Bacchetti S; Evelegh MJ; Muirhead B
Journal
Journal of Virology, Vol. 57, No. 3, pp. 1177–1181
Publisher
American Society for Microbiology
Publication Date
March 1986
DOI
10.1128/jvi.57.3.1177-1181.1986
ISSN
0022-538X