Journal article
SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN
Abstract
PTEN is post-translationally modified by ubiquitin via association with multiple E3 ubiquitin ligases, including NEDD4-1, XIAP, and WWP2. Despite the rapid progress made in researching the impact of ubiquitination on PTEN function, our understanding remains fragmented. Building on the previously observed interaction between SIPL1 and PTEN, we report here that SIPL1 promotes PTEN polyubiquitination via lysine 48 (K48)-independent polyubiquitin …
Authors
De Melo J; Lin X; He L; Wei F; Major P; Tang D
Journal
Cellular Signalling, Vol. 26, No. 12, pp. 2749–2756
Publisher
Elsevier
Publication Date
December 2014
DOI
10.1016/j.cellsig.2014.08.013
ISSN
0898-6568