Comparative Effectiveness Research Paradigm: Implications for Systematic Reviews and Clinical Practice Guidelines

PURPOSE: The objectives of this article are (1) to examine the similarities and differences between comparative effectiveness research (CER) and evidence-based medicine (EBM); (2) to describe the implications of CER for systematic review methodologies in oncology; and (3) to address the transition from systematic reviews to guideline development and the implications of CER in this process. METHOD: An analysis of the principles and methods of …