Journal article
Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar
Abstract
We used microPET to map the dose-response to the novel P-glycoprotein (P-gp) inhibitor tariquidar (TQD) of the initial influx of the P-gp substrate [(18)F]-MPPF in rat brain, and to test for effects of P-gp inhibition on the subsequent binding of [(18)F]-MPPF to serotonin 5-HT(1A) receptors. Summation maps of [(18)F]-MPPF uptake during the first 100 seconds after intravenous injection were calculated in groups of rats with vehicle (glucose 5%) …
Authors
la Fougère C; Böning G; Bartmann H; Wängler B; Nowak S; Just T; Wagner E; Winter P; Rominger A; Förster S
Journal
NeuroImage, Vol. 49, No. 2, pp. 1406–1415
Publisher
Elsevier
Publication Date
January 2010
DOI
10.1016/j.neuroimage.2009.09.048
ISSN
1053-8119
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily B, Member 1AnimalsBrainCentral Nervous System AgentsDose-Response Relationship, DrugFemalePiperazinesPositron-Emission TomographyPyridinesQuinolinesRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1AReproducibility of ResultsSerotonin 5-HT1 Receptor AntagonistsSerotonin AntagonistsTime FactorsVentricular Function, Left