Journal article
Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets
Abstract
We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. …
Authors
Nachbagauer R; Miller MS; Hai R; Ryder AB; Rose JK; Palese P; García-Sastre A; Krammer F; Albrecht RA
Journal
Journal of Virology, Vol. 90, No. 6, pp. 3268–3273
Publisher
American Society for Microbiology
Publication Date
March 15, 2016
DOI
10.1128/jvi.02481-15
ISSN
0022-538X