Journal article
Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals 1 , 2 , 3 , 4 , 5
Abstract
BACKGROUND: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain.
OBJECTIVE: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive aging.
Authors
Clarke R; Bennett D; Parish S; Lewington S; Skeaff M; Eussen SJ; Lewerin C; Stott DJ; Armitage J; Hankey GJ
Journal
American Journal of Clinical Nutrition, Vol. 100, No. 2, pp. 657–666
Publisher
Elsevier
Publication Date
August 2014
DOI
10.3945/ajcn.113.076349
ISSN
0002-9165