Journal article
Bacteria Challenge in Smoke-exposed Mice Exacerbates Inflammation and Skews the Inflammatory Profile
Abstract
RATIONALE: The pathogenesis of chronic obstructive pulmonary disease is associated with acute episodes of bacterial exacerbations. The most commonly isolated bacteria during episodes of exacerbation is nontypeable Haemophilus influenzae (NTHI).
OBJECTIVES: In this study, we investigated the in vivo consequences of cigarette smoke exposure on the inflammatory response to an NTHI challenge.
Authors
Gaschler GJ; Skrtic M; Zavitz CCJ; Lindahl M; Onnervik P-O; Murphy TF; Sethi S; Stämpfli MR
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 179, No. 8, pp. 666–675
Publisher
Oxford University Press (OUP)
Publication Date
April 15, 2009
DOI
10.1164/rccm.200808-1306oc
ISSN
1073-449X