Journal article
Cigarette Smoke Exposure Attenuates Cytokine Production by Mouse Alveolar Macrophages
Abstract
Alveolar macrophages (aMs) play a central role in respiratory host defense by sensing microbial antigens and initiating immune-inflammatory responses early in the course of an infection. The purpose of this study was to investigate the effect of cigarette smoke exposure on aMs after stimulation of innate pattern recognition receptors (PRRs) in a murine model. To accomplish this, C57BL/6 mice were exposed for 8 weeks using two models of …
Authors
Gaschler GJ; Zavitz CCJ; Bauer CMT; Skrtic M; Lindahl M; Robbins CS; Chen B; Stämpfli MR
Journal
American Journal of Respiratory Cell and Molecular Biology, Vol. 38, No. 2, pp. 218–226
Publisher
American Thoracic Society
Publication Date
February 2008
DOI
10.1165/rcmb.2007-0053oc
ISSN
1044-1549