Journal article
Caveolin-1 deficiency protects against mesangial matrix expansion in a mouse model of type 1 diabetic nephropathy
Abstract
Aims/hypothesisGlomerular matrix protein accumulation, mediated largely by resident mesangial cells (MCs), is central to the pathogenesis of diabetic nephropathy. We previously showed that caveolin (CAV)-1/caveolae mediate matrix upregulation by MCs in response to high glucose and TGFβ, two important pathogenic mediators of diabetic glomerular sclerosis. Here, we evaluated the in vivo role of CAV-1/caveolae in the development of diabetic …
Authors
Guan TH; Chen G; Gao B; Janssen MR; Uttarwar L; Ingram AJ; Krepinsky JC
Journal
Diabetologia, Vol. 56, No. 9, pp. 2068–2077
Publisher
Springer Nature
Publication Date
September 2013
DOI
10.1007/s00125-013-2968-z
ISSN
0012-186X