Journal article
TGFβ-induced RhoA activation and fibronectin production in mesangial cells require caveolae
Abstract
Glomerular sclerosis of diverse etiologies is characterized by mesangial matrix accumulation, with transforming growth factor-beta (TGFbeta) an important pathogenic factor. The GTPase RhoA mediates TGFbeta-induced matrix accumulation in some settings. Here we study the role of the membrane microdomain caveolae in TGFbeta-induced RhoA activation and fibronectin upregulation in mesangial cells (MC). In primary rat MC, TGFbeta1 time dependently …
Authors
Peng F; Zhang B; Wu D; Ingram AJ; Gao B; Krepinsky JC
Journal
American Journal of Physiology. Renal physiology, Vol. 295, No. 1, pp. f153–f164
Publisher
American Physiological Society
Publication Date
July 2008
DOI
10.1152/ajprenal.00419.2007
ISSN
0363-6127