Journal article
Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis
Abstract
Background:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated with prostate cancer (PC) remains unclear.Methods:ALDH3A1 expression was analysed in various PC cell lines. Xenograft tumours and …
Authors
Yan J; De Melo J; Cutz J-C; Aziz T; Tang D
Journal
British Journal of Cancer, Vol. 110, No. 10, pp. 2593–2603
Publisher
Springer Nature
Publication Date
May 2014
DOI
10.1038/bjc.2014.201
ISSN
0007-0920
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenocarcinomaAldehyde DehydrogenaseAndrogensAnimalsBone NeoplasmsCell Line, TransformedCell Line, TumorCell Transformation, NeoplasticDisease ProgressionEnzyme InductionEpithelial CellsGene Expression Regulation, NeoplasticHumansLung NeoplasmsLymphatic MetastasisMaleMiceMice, Inbred NODMice, SCIDNeoplasm ProteinsNeoplasm TransplantationNeoplasms, Hormone-DependentNeoplastic Stem CellsProstatic Intraepithelial NeoplasiaProstatic Neoplasms