Journal article
Dose–response effects of TPI ASM8 in asthmatics after allergen
Abstract
BACKGROUND: TPI ASM8 contains two modified antisense oligonucleotides (AON) targeting the beta subunit (β(c) ) of the IL-3, IL-5, GM-CSF receptors and the chemokine receptor CCR3. A previous study suggested that TPI ASM8 had broader effects than just inhibition of eosinophils in asthmatics.
OBJECTIVE: We assessed whether TPI ASM8 caused a dose-dependent attenuation in the inflammatory and physiological changes after inhaled allergen challenge …
Authors
Gauvreau GM; Pageau R; Séguin R; Carballo D; Gauthier J; D’Anjou H; Campbell H; Watson R; Mistry M; Parry‐Billings M
Journal
Allergy, Vol. 66, No. 9, pp. 1242–1248
Publisher
Wiley
Publication Date
September 2011
DOI
10.1111/j.1398-9995.2011.02638.x
ISSN
0001-5148