Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

Lymphatic defence against neurotropic virusesMicroorganisms that breach the body's external defences and enter the lymphatic system are liable to be captured by the lymph nodes, and recent work showed that a subset of macrophages found in the subcapsular sinus (SCS) of lymph nodes is critical for clearance of viruses from the lymph and for initiating antiviral humoral immune responses. Now a third function for SCS macrophages has been …