Journal article
IL-4 and IL-13 Differentially Regulate TLR-Induced Eosinophil-Basophil Differentiation of Cord Blood CD34+ Progenitor Cells
Abstract
Intrauterine environmental exposures have been shown to influence neonatal immunity and subsequent allergic disease development. We have previously shown that fewer lipopolysaccharide (LPS)-stimulated eosinophil-basophil (Eo/B) colonies grow from cord blood (CB) of high-atopic risk infants, compared to low-atopic risk infants. In the present study, we investigated whether a surrogate ex vivo TH2 milieu (i.e., either IL-4 or IL-13) could …
Authors
Reece P; Gauvreau GM; Sehmi R; Denburg JA
Journal
PLOS ONE, Vol. 9, No. 6,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0100734
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Antigens, CD34BasophilsCell Culture TechniquesCell DifferentiationCells, CulturedEosinophilsFetal BloodGranulocyte-Macrophage Colony-Stimulating FactorHumansInterleukin-13Interleukin-13 Receptor alpha1 SubunitInterleukin-4Interleukin-4 Receptor alpha SubunitLipopolysaccharidesMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3PhosphorylationReceptors, Interleukin-13Signal TransductionStem CellsToll-Like Receptors