Journal article
Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent
Abstract
BACKGROUND: Thymic stromal lymphopoietin (TSLP) released after antigenic stimulation of allergic asthmatic airways is a key initiator of type 2 inflammation. Basophils are important effectors of allergic inflammation in the airways. Murine basophils have been shown to respond to TSLP independently of IL-3 by increasing functional thymic stromal lymphopoietin receptor (TSLPR) expression.
OBJECTIVE: The purpose of this study was to investigate …
Authors
Salter BM; Oliveria JP; Nusca G; Smith SG; Watson RM; Comeau M; Sehmi R; Gauvreau GM
Journal
The Journal of Allergy and Clinical Immunology, Vol. 136, No. 6, pp. 1636–1644
Publisher
Elsevier
Publication Date
December 2015
DOI
10.1016/j.jaci.2015.03.039
ISSN
0091-6749