Journal article
Genetically Determined Disparate Innate and Adaptive Cell-Mediated Immune Responses to Pulmonary Mycobacterium bovis BCG Infection in C57BL/6 and BALB/c Mice
Abstract
The current study was designed to investigate the impact of genetic heterogeneity on host immune responses to pulmonary intracellular infection by using two mouse strains of distinct genetic background, C57BL/6 and BALB/c mice, and a model intracellular pathogen, Mycobacterium bovis BCG. Upon infection, compared to C57BL/6 mice, BALB/c mice developed an earlier response of interleukin 12 (IL-12), gamma interferon (IFN-gamma), tumor necrosis …
Authors
Wakeham J; Wang J; Xing Z
Journal
Infection and Immunity, Vol. 68, No. 12, pp. 6946–6953
Publisher
American Society for Microbiology
Publication Date
December 2000
DOI
10.1128/iai.68.12.6946-6953.2000
ISSN
0019-9567