Murine Airway Luminal Antituberculosis Memory CD8 T Cells by Mucosal Immunization Are Maintained Via Antigen-Driven In Situ Proliferation, Independent of Peripheral T Cell Recruitment

RATIONALE: The airway luminal memory CD8 T cells induced by respiratory mucosal immunization in a murine model have been found to be critical to antituberculosis immunity. However, the mechanisms of their maintenance on airway mucosal surface still remain poorly understood. OBJECTIVES: Using a model of adenovirus-based intranasal immunization we investigated the immune property and the mechanisms of maintenance of airway luminal CD8 T cells.