A novel genetically engineered Mycobacterium smegmatis-based vaccine promotes anti-TB immunity

Abstract

Pulmonary TB remains a global health threat. Prophylactic immunization with Mycobacterium bovis BCG is the only key strategy to control TB. Ineffectiveness of BCG immunization in TB-endemic areas and BCG-related safety issues in HIV-positive infants have prompted the development of new TB vaccines. As enhanced understanding of the immune evasion mechanism of Mycobacterium tuberculosis will help develop new vaccines, Sweeney et al. studied the …