Journal article
Heterologous Boosting of Recombinant Adenoviral Prime Immunization With a Novel Vesicular Stomatitis Virus–vectored Tuberculosis Vaccine
Abstract
Pulmonary tuberculosis (TB) remains a serious health problem worldwide. Effective vaccination strategies are needed. We report the development of a novel TB vaccine using vesicular stomatitis virus (VSV) as a viral vector system to express Ag85A. VSVAg85A was shown to be immunogenic when given to mice by either an intranasal or an intramuscular (i.m.) route. Although distinct T-cell profiles resulted from both routes of immunization, only …
Authors
Roediger EK; Kugathasan K; Zhang X; Lichty BD; Xing Z
Journal
Molecular Therapy, Vol. 16, No. 6, pp. 1161–1169
Publisher
Elsevier
Publication Date
June 2008
DOI
10.1038/mt.2008.59
ISSN
1525-0016