Journal article
A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice
Abstract
The tight skin (Tsk/+) mouse represents a murine model of heritable fibrosis with some similarities to the skin fibrosis seen in human scleroderma. Tsk/+ animals display alterations in connective tissue in some internal organs. Skin fibrosis can be adoptively transferred to normal recipients with Tsk/+ bone marrow or spleen cells and older Tsk/+ animals develop autoantibodies against topoisomerase suggesting that some of the pathogenesis in the …
Authors
Wallace VA; Kondo S; Kono T; Xing Z; Timms E; Furlonger C; Keystone E; Gauldie J; Sauder DN; Mak TW
Journal
European Journal of Immunology, Vol. 24, No. 6, pp. 1463–1466
Publisher
Wiley
Publication Date
June 1994
DOI
10.1002/eji.1830240634
ISSN
0014-2980