Journal article
Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia
Abstract
Intranasal instillation techniques are used to deliver various substances to the upper and lower respiratory tract (URT and LRT) in mice. Here, we quantify the relative distribution achieved with intranasal delivery of a nonabsorbable tracer, (99m)Tc-labeled sulfide-colloid. Relative distribution was determined by killing mice after instillation and quantifying the radioactivity in dissected tissues using gamma scintigraphy. A significant …
Authors
Southam DS; Dolovich M; O'Byrne PM; Inman MD
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 282, No. 4, pp. l833–l839
Publisher
American Physiological Society
Publication Date
April 1, 2002
DOI
10.1152/ajplung.00173.2001
ISSN
1040-0605