Isoprostanes: Generation, Pharmacology, and Roles in Free-radical-mediated Effects in the Lung

Isoprostanes are produced during peroxidation of membrane lipids by free radicals and reactive oxygen species, and are currently used as markers of many disease states and experimental conditions in which oxidative stress is a prominent feature. A small number of reports have described the ability of some isoprostanes to evoke important biological effects in smooth muscle and other cell types. However, most of these studies were done using rat …