Journal article
Depolarizing agents induce oscillations in canine bronchial smooth muscle membrane potential: possible mechanisms.
Abstract
Tetraethylammonium (TEA) 925 mM), 4-aminopyridine (4-AP) (5 mM) and carbachol (3 X 10(-7) M) elicited membrane depolarization (approximately 20 mV) and oscillation (0.5-1.0 Hz; up to 25 mV in amplitude) in canine bronchi (3rd to 5th order). BaCl2 (1 mM) also elicited large depolarizations but not oscillations. The oscillations were antagonized by nitrendipine (NT) (10(-8) M) or atropine (10(-6) M) and were unaffected by phentolamine, …
Authors
Janssen LJ; Daniel EE
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 259, No. 1, pp. 110–117
Publisher
Elsevier
Publication Date
October 1991
DOI
10.1016/s0022-3565(25)20254-3
ISSN
0022-3565