Journal article
Vasodilatory and Electrophysiological Actions of 8-iso-Prostaglandin E2 in Porcine Coronary Artery
Abstract
We examined the effects of several E-ring and F-ring isoprostanes on mechanical and electrophysiological activity in porcine coronary artery. Several isoprostanes evoked concentration-dependent contractions, with 8-iso-PGE2 being the most potent (-log EC50 of 6.9 +/- 0.1); this excitatory effect has been described in detail elsewhere and was not examined further here. 8-iso-PGE2 evoked dose-dependent relaxations in tissues preconstricted with …
Authors
Zhang Y; Tazzeo T; Hirota S; Janssen LJ
Journal
Journal of Pharmacology and Experimental Therapeutics, Vol. 305, No. 3, pp. 1054–1060
Publisher
Elsevier
Publication Date
June 2003
DOI
10.1124/jpet.103.049353
ISSN
0022-3565