Journal article
Cysteinyl Leukotrienes Promote Human Airway Smooth Muscle Migration
Abstract
Cysteinyl leukotrienes promote airway smooth muscle (ASM) contraction and proliferation. Little is known about their role in ASM migration. We investigated this using cultured human ASMs (between the second and fifth passages) obtained from the large airways of resected nonasthmatic lung. Platelet-derived growth factor-BB (1 ng/ml) promoted significant (3.5-fold) ASM migration of myocytes across collagen-coated 8- micro m polycarbonate …
Authors
Parameswaran K; Cox G; Radford K; Janssen LJ; Sehmi R; O'Byrne PM
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 166, No. 5, pp. 738–742
Publisher
Oxford University Press (OUP)
Publication Date
September 2002
DOI
10.1164/rccm.200204-291oc
ISSN
1073-449X