Journal article
Integrins are Mechanosensors That Modulate Human Eosinophil Activation
Abstract
Eosinophil migration to the lung is primarily regulated by the eosinophil-selective family of eotaxin chemokines, which mobilize intracellular calcium (Ca(2+)) and orchestrate myriad changes in cell structure and function. Eosinophil function is also known to be flow-dependent, although the molecular cognate of this mechanical response has yet to be adequately characterized. Using confocal fluorescence microscopy, we determined the effects of …
Authors
Ahmadzai M; Small M; Sehmi R; Gauvreau G; Janssen LJ
Journal
Frontiers in Immunology, Vol. 6, ,
Publisher
Frontiers
DOI
10.3389/fimmu.2015.00525
ISSN
1664-3224