Journal article
The bronchodilators 8-iso-prostaglandin E2 and prostaglandin E2 induce K+ current suppression via thromboxane A2 receptors in porcine tracheal smooth muscle
Abstract
We examined relaxations and changes in K(+) current evoked by 8-iso-prostaglandin E(2) and prostaglandin E(2) in porcine tracheal smooth muscle. Both autacoids completely reversed cholinergic tone; blockade of thromboxane A(2) receptors had no effect on relaxations to either compound. 8-iso-prostaglandin E(2) and prostaglandin E(2) suppressed outward K(+) currents while the thromboxane A(2) receptor agonist U46619 (9, …
Authors
Helli PB; Catalli A; Janssen LJ
Journal
European Journal of Pharmacology, Vol. 501, No. 1-3, pp. 179–184
Publisher
Elsevier
Publication Date
October 2004
DOI
10.1016/j.ejphar.2004.08.021
ISSN
0014-2999