Journal article
Pharmacological actions of isoprostane metabolites and phytoprostanes in human and bovine pulmonary smooth muscles
Abstract
We examined the responses to various isoprostane derivatives in bovine/human airway and pulmonary arteries. All biological activity of 15-F(2t)-IsoP was lost in its two major metabolites (15-keto-15-F(2t)-IsoP and 13,14-dihydro-15-keto-15-F(2t)-IsoP). We also examined the effects of several metabolites of 15-F(2t)-IsoP synthesized within our own laboratory-both epimers of 2,3-dinor-15-F(2t)-IsoP and of 2,3-dinor-5,6-dihydro-15-F(2t)-IsoP, as …
Authors
Liu C; Tazzeo T; Guy A; Durand T; Janssen LJ
Journal
Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 76, No. 1, pp. 57–64
Publisher
Elsevier
Publication Date
January 2007
DOI
10.1016/j.plefa.2006.08.005
ISSN
0952-3278