Journal article
Alteration of arterial smooth muscle potassium channel composition and BKCa current modulation in hypertension
Abstract
We investigated K+ currents and their regulation by the sarcoplasmic reticulum in mesenteric arterial smooth muscle cells of the spontaneously hypertensive rat (SHR). Using perforated patch-clamp technique, we found the overall K+ current density was significantly lower in adult SHR compared to adult Wistar-Kyoto rats (WKY). The K+ currents were almost exclusively of large-conductance Ca2+-dependent (BK(Ca)) variety in SHR, but largely of …
Authors
Zhang Y; Gao Y-J; Zuo J; Lee RMKW; Janssen LJ
Journal
European Journal of Pharmacology, Vol. 514, No. 2-3, pp. 111–119
Publisher
Elsevier
Publication Date
May 2005
DOI
10.1016/j.ejphar.2005.03.032
ISSN
0014-2999
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsBlotting, WesternBoron CompoundsCaffeineCalciumCells, CulturedDose-Response Relationship, DrugHypertensionIndolesMembrane PotentialsMesenteric ArteriesMuscle, Smooth, VascularMyocytes, Smooth MusclePotassium Channel BlockersPotassium ChannelsRatsRats, Inbred SHRRats, Inbred WKYRyanodineSarcoplasmic ReticulumTetraethylammoniumTime Factors