The Ethical Space of Engagement, as articulated by Nêhiyaw scholar Willie Ermine, offers a framework for respectful dialogue between distinct worldviews. While recent scholarship has applied this framework to practice-level relationships in behavior analysis, this paper extends the framework to the design, evaluation, and transformation of complex cultural systems using culturo-behavioral systems science (CBSS). We propose a systems-level expansion of Ethical Space comprising four interdependent components: (1) mutual engagement, (2) systemic advocacy, (3) culturally responsive leadership, and (4) power redistribution. Each component is examined through core CBSS concepts, including interlocking behavioral contingencies, metacontingencies, macrocontingencies, and culturo-behavioral hypercycles, to demonstrate how relational values can be operationalized into structural change. By integrating the Ethical Space of Engagement with CBSS, this paper provides behavior analysts with a functional-analytic framework for advancing equity across organizational and societal contexts. This model positions Ethical Space not only as a relational practice but as a rigorous system-design framework for disrupting inequitable cultural patterns and fostering sustainable, prosocial environments.