Optimized methods for production and purification of Titanium-45

Titanium-45 (t_1/2 = 3.08 h) is a radiometal with excellent nuclear characteristics, including a high positron branching ratio (85%) and low average positron energy (0.439 MeV), for the development of PET imaging agents. ⁴⁵Ti was produced via the ⁴⁵Sc(p,n)⁴⁵Ti reaction on the University of Alabama at Birmingham TR24 cyclotron in GBq quantities. Optimized separation methods were developed and preliminary radiochemistry studies were also carried out. This work shows ⁴⁵Ti is a promising radiometal for future studies.