The use of 111 Ag as a tool for studying biological distribution of silver-based antimicrobials

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified ¹¹¹Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [¹¹¹Ag]SCC1 and investigated in biodistribution studies.