Home
Scholarly Works
Cover Picture: A Rapid, Amplification‐Free, and...
Journal article

Cover Picture: A Rapid, Amplification‐Free, and Sensitive Diagnostic Assay for Single‐Step Multiplexed Fluorescence Detection of MicroRNA (Angew. Chem. Int. Ed. 34/2015)

Abstract

The simple, sensitive, and selective detection of short‐sequence microRNAs is very challenging. In their Communication on page 10024 ff. N. Hildebrandt and co‐workers present a single‐step “mix‐and‐measure” FRET assay for the multiplexed detection of different microRNAs. The careful design of the biophotonic probe and time‐gated FRET from a luminescent Tb complex to three difference fluorescent dyes are crucial to this microRNA test for multiplexed clinical diagnostics.

Authors

Jin Z; Geißler D; Qiu X; Wegner KD; Hildebrandt N

Journal

Angewandte Chemie International Edition, Vol. 54, No. 34, pp. 9725–9725

Publisher

Wiley

Publication Date

August 17, 2015

DOI

10.1002/anie.201506281

ISSN

1433-7851

Labels

View published work (Non-McMaster Users)