Emerging paradigms in the study of brain...

Emerging paradigms in the study of brain metastases

Abstract

Brain metastases arise from the spread of cancer cells from tumors residing outside the brain. Immunotherapy and molecularly targeted therapeutics have improved outcomes for some patients with brain metastases, but many patients are still faced with a dismal prognosis. The inability to effectively treat these tumors and improve patient survival highlights the dire need for improved therapeutic strategies that ultimately depend on developing a greater understanding of the molecular underpinnings and inner wiring of these tumors. In this Review, we discuss current and emerging insights into the genetics and cellular signaling pathways that contribute to the spread of tumors to the brain. We also discuss potential therapeutic targets in the metabolic vulnerabilities of cells that metastasize to the brain and in the interactions between metastases and the microenvironment.

Authors

Chafe SC; Mobilio D; Zhai K; Kieliszek AM; Venugopal C; Singh SK

Journal

Science Signaling, Vol. 19, No. 932,

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

April 7, 2026

DOI

10.1126/scisignal.adj9726

ISSN

1945-0877

Associated Experts

Sheila Singh

Professor (Part-Time), Faculty of Health Sciences

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