Journal article
Pathogenic IgE-fated memory B cell responses retain functional plasticity
Abstract
Long-lived immunoglobulin E (IgE) responses against innocuous environmental and dietary antigens (Ags) are maintained by an IgG1-dominant memory B cell (MBC) compartment primed for interleukin-4 (IL-4) responsiveness. The plasticity of the MBC compartment destined for IgE class switch recombination remains poorly understood. In this work, we report critical IL-4 and IL-13 dependency for the pathogenic IgE fate of type 2-polarized MBCs in …
Authors
Bruton K; Phelps A; Ariaz A; Fang A; Walker TD; Wen J; Khavkine-Binstock SS; Della Libera D; Mann-Delany O; Knudsen NPH
Journal
Science Immunology, Vol. 11, No. 115,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
January 2, 2026
DOI
10.1126/sciimmunol.ady2268
ISSN
2470-9468