Journal article
miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1
Abstract
Glomerular extracellular matrix protein accumulation, mediated largely by mesangial cells(MC), is a defining feature of diabetic kidney disease(DKD). Previously we showed that TGFβ1, a profibrotic cytokine in kidney fibrosis, inhibits expression of the antifibrotic follistatin through induction of microRNA-299a-5p. Whether this microRNA contributes to DKD is unknown. We show that microRNA-299a-5p is increased in mouse and human diabetic …
Authors
Nmecha IK; Gao B; MacDonald M; Zhang D; Choi J; Trink J; Bajwa U; Krepinsky JC
Journal
Communications Biology, , ,
Publisher
Springer Nature
Publication Date
December 11, 2025
DOI
10.1038/s42003-025-09271-6
ISSN
2399-3642