Journal article
Resolution of Angiographic Macular Leakage with Faricimab versus Aflibercept in Patients with Diabetic Macular Edema in YOSEMITE/RHINE
Abstract
PURPOSE: To evaluate if dual angiopoietin-2 (Ang-2)/VEGF-A inhibition with faricimab resulted in greater macular leakage resolution versus aflibercept in patients with diabetic macular edema (DME).
DESIGN: Post hoc analysis of macular leakage assessments prespecified in the YOSEMITE/RHINE (NCT03622580/NCT03622593) phase III trials.
Authors
Goldberg RA; Mar FA; Csaky K; Amador M; Khanani AM; Gibson K; Kolomeyer AM; Sim DA; Murata T; Wang T
Journal
Ophthalmology Retina, Vol. 9, No. 6, pp. 515–526
Publisher
Elsevier
Publication Date
6 2025
DOI
10.1016/j.oret.2024.11.015
ISSN
2468-6530
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AgedFemaleHumansMaleMiddle AgedAngiogenesis InhibitorsCapillary PermeabilityDiabetic RetinopathyDose-Response Relationship, DrugDouble-Blind MethodFluorescein AngiographyFollow-Up StudiesFundus OculiIntravitreal InjectionsMacula LuteaMacular EdemaReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsTomography, Optical CoherenceTreatment OutcomeVascular Endothelial Growth Factor AVisual AcuityAntibodies, Bispecific