BackgroundHealth-system leaders are increasingly faced with making decisions about whether and how to use a wide range of current and emerging health-system innovations to address complex system and policy challenges. Health-system innovations can broadly include new ways of doing things at a system level, such as new approaches to govern health systems, care delivery, funding models, health policy or better ways to integrate health and social services. However, Canada has historically struggled with the adaptation and uptake of health-system innovations. This multicomponent study aimed to explore the challenges, approaches and implementation considerations for creating an integrated innovation system that enables the adaptation and uptake of health-system innovations from the perspectives of citizens and health system leaders in Canada.MethodsWe synthesized the best-available evidence into an evidence brief and a subsequent plain-language version (a citizen brief) in consultation with a steering committee and key informants, including policymakers, leaders of systems, organizations and professional organizations, industry representatives, citizen leaders and researchers. These briefs informed deliberations in four citizen panels (n = 48 participants) and a national stakeholder dialogue with health-system leaders (n = 23 participants) to identify key challenges, approaches, implementation considerations and next steps that could be taken.ResultsCitizen panel participants and health-system leaders highlighted barriers such as culture and mindsets that resist health-system innovations, limited targeted funding for health-system innovations and processes that encourage sustainability, lack of mechanisms to adapt health-system innovation in local contexts and limited health human resources due to competing interests across health systems. Both groups emphasized the need for people-centred approaches to establish shared goals and vision, identify gaps and map what has worked to drive health-system innovations, set priorities and discuss how each stakeholder group can contribute to building and reviewing implementation considerations such as resources and funding related for the adaptation and uptake of health-system innovations.ConclusionsThe findings provide insight for ongoing efforts to improve the development, implementation and evaluation efforts to enhance and harness health-system innovation to strengthen health systems in Canada. Collaboration from within and between governments and sectors will ultimately help to increase the value gained from health-system innovations.