Commentary: The many roles of decision thresholds for primary research, evidence synthesis and health decision-making

A decision threshold (DT) reflects the point at which a decision or judgment changes, leading to the selection of an action or a commitment for one of several alternatives. Thresholds have always played a role in decision-making. Very small effects may achieve statistical significance yet remain not important to patients or the public. Judgments shift, for instance, from "no or trivial effect" to "small, moderate and large benefit" with direct …