Abstract B58: Functional analysis of the cell adhesion molecule Nectin-4 in the unique tumor microenvironment of ovarian cancer.

Abstract A unique aspect of ovarian cancer progression is the collection of ascites fluid in the abdominal cavity, which contains free-floating tumor cells in the form of single cells and multicellular aggregates (spheroids). In previous studies, we showed that the cell adhesion molecule Nectin-4 is overexpressed in ovarian cancer tumors and that the soluble fragment of Nectin-4 (sN4) is detected in the ascites fluid and sera …