Journal article
Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma
Abstract
BackgroundCancer stem cells (CSC) may respond to chemotherapy differently from other tumor cells.MethodsThis study examined the expression of the putative cancer stem cell markers ALDH1, CD44, and CD133; the angiogenesis marker CD31; and the macrophage marker CD68 in soft tissue sarcomas (STS) before and after 4 cycles of chemotherapy with doxorubicin and ifosfamide in 31 patients with high-grade soft tissue sarcoma in a prospective clinical …
Authors
Skubitz KM; Wilson JD; Cheng EY; Lindgren BR; Boylan KLM; Skubitz APN
Journal
Journal of Translational Medicine, Vol. 17, No. 1,
Publisher
Springer Nature
Publication Date
12 2019
DOI
10.1186/s12967-019-1883-6
ISSN
1479-5876