Journal article
Overexpression of DOC-1R Inhibits Cell Cycle G1/S Transition by Repressing CDK2 Expression and Activation
Abstract
DOC-1R (deleted in oral cancer-1 related) is a novel putative tumor suppressor. This study investigated DOC-1R antitumor activity and the underlying molecular mechanisms. Cell phenotypes were assessed using flow cytometry, BrdU incorporation and CDK2 kinase assays in DOC-1R overexpressing HeLa cells. In addition, RT-PCR and Western blot assays were used to detect underlying molecular changes in these cells. The interaction between DOC-1R and …
Authors
Liu Q; Liu X; Gao J; Shi X; Hu X; Wang S; Luo Y
Journal
International Journal of Biological Sciences, Vol. 9, No. 6, pp. 541–549
Publisher
Ivyspring International Publisher
Publication Date
2013
DOI
10.7150/ijbs.5763
ISSN
1449-2288