Myocardial autophagy as a compensatory response to Doxorubicin-induced cardiotoxicity
Abstract
Doxorubicin (Doxo) is an anthracycline antibiotic commonly used in the treatment of a wide range of cancers. Doxo is known for its cumulative dose-dependent cardiotoxicity leading to dilated cardiomyopathy, congestive heart failure and death. To date the precise molecular events contributing to these adverse reactions are not fully understood. Autophagy is a catabolic process, tightly regulated, involved in the recycling of cytoplasmic components and organelles. It is characterized by sequestration of cytosolic constituents in autophagosomes that fuse with lysosomes to form autolysosomes. Here we test the hypothesis that Doxo-dependent cytotoxic stress induces autophagy in the heart
Authors
Dimitrakis P; Konecny F; Zuppinger C; von Harsdorf R