Journal article
Identification and characterization of botulinum neurotoxin–like two-component toxins in Paeniclostridium ghonii
Abstract
Insecticidal bacterial proteins play key roles in insect-bacteria interactions and have been used as biopesticides. Here, we identify two insecticidal proteins in Paeniclostridium ghonii, designated PG-toxin 1 (PG1) and PG-toxin 2 (PG2), which are homologs of botulinum neurotoxins (BoNTs). Unlike BoNTs, PG1 and PG2 contain two separate proteins: One is the protease light chain (LC), and the other is the heavy chain containing the translocation …
Authors
Lee P-G; Yin L; Wei X; Shi J; Masuyer G; Wentz TG; Chen P; Xu Y; Liang J; Zhang H
Journal
Science Advances, Vol. 11, No. 46,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
November 14, 2025
DOI
10.1126/sciadv.adx6145
ISSN
2375-2548