Tumour growth and chemotherapy alter skeletal muscle, cardiac, and hepatic amino acid pools in mice

Background: Amino acids (AAs) play structural and metabolic roles in muscle, heart, and liver-tissues impacted by cancer and chemotherapy. Changes in AA profiles within these tissues have not been evaluated in response to tumor growth and chemotherapy. This study investigated how tumor growth with or without Doxorubicin altered tissue-level amino acids. Methods: Female C57bl/6 mice (n = 7-10/group) were randomly assigned to groups: Control, …